A new in vivo pharmacokinetic recall study involving 114 participants in the Estonian Biobank has provided the first clinical confirmation that previously uncharacterized genetic variants in the ...

Study in JAMA details about 100 gene variants that present as four distinct phenotypes. An international team of scientists has found that natural variations in breast cancer patients’ cytochrome P450 ...

In recent years, scientists discovered that an enzyme called CYP2D6 could possibly predict whether a patient would respond to the drug. Small studies aimed at confirming the predictive link, however, ...

The evidence of CYP2D6 genotype–phenotype correlation associated with tamoxifen pharmacokinetics in early breast cancer is compelling. However, the scientific community is currently divided on the ...

An enzyme called CYP2D6 converts tamoxifen to its active form, and some research has suggested that if the enzyme is blocked, tamoxifen won’t be as effective, thus causing patients to recur sooner ...

When taken together, the pain medication tramadol and certain antidepressants may raise seizure risk in older adults, according to a new study. Researchers studied people living in nursing homes ...