Due to rising costs and the difficulty to identify new targets, drug repurposing appears as a viable strategy for the development of new anti-cancer treatments. Although the interest of disulfiram ...

Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer's disease, and a study led by the University of California San Diego provides new ...

A study led by University of California, San Diego (UCSD), scientists has provided new evidence to support their suggestion that elevated levels of an enzyme called phosphoglycerate dehydrogenase ...

Blocking PHGDH in tumors that overexpress it halts cell proliferation and cancer growth in vitro and in vivo. The enzyme phosphoglycerate dehydrogenase (PHGDH) may represent a therapeutic target for ...

Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer's disease, and a study led by the University of California San Diego provides new ...

The majority of the mammalian skeleton is formed through endochondral ossification starting from a cartilaginous template. Cartilage cells, or chondrocytes, survive, proliferate and synthesize ...

Using a new approach, scientists at The Scripps Research Institute (TSRI) and collaborating institutions have discovered a novel drug candidate that could be used to treat certain types of breast ...

A dietary supplement believed to protect against Alzheimer's disease might instead be potentially harmful to the brain, a new study warns. L-serine is an amino acid that serves many different roles in ...

The complex changes in the body that underpin dementia - a general term for symptoms associated with progressive brain decline - is the subject of ongoing research. A new study published in Cell ...

Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer's disease. Researchers have consistently found high levels of PHGDH expression in ...