Zonulin is a protein that modulates the permeability of tight junctions between the cells of your gut lining. High levels can induce the breakdown of tight junctions. When we say that zonulin modulates the intestinal permeability, it is helpful to think of the lining of the intestines as a cheesecloth. Only the tiniest particles should pass through. Zonulin makes the holes of the cheesecloth bigger and allows large particles to pass into the bloodstream and through the body. We call this increas
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